Zack Scholl



Zackary Scholl, Ph.D. is a biophysicist interested in the mechanisms of protein folding and studies them with theory and experiment at the single-molecule level.

I am a native Oregonian, born in Portland. I am interested in studying the protein mediated biochemical processes using nanotechnology. I am also interested in improving tools to manipulate single molecules, including force spectroscopy and molecular dynamic simulations.

I have a B.S. in Physics (University of Washington), B.S. in Applied Computational Math Science (University of Washington), and a Ph.D. in Computational Biology and Bioinformatics (Duke University).


Teaching statement


* denotes equal contributions.

Li, Q.*, Scholl, Z. N.*, & Marszalek, P. E. (2018). Unraveling the unfolding pathways of yeast phosphoglycerate kinase. Biophysical Journal.

Plata, C., Scholl, Z. N., Marszalek, P. E. & Prados A. (2018). Relevance of the Speed and Direction of Pulling in Simple Modular Proteins. Journal of Chemical Theory and Computation.

Mojumdar S. S., Scholl, Z. N., Dee D. R., Rouleau L., Anand U., Garden C., & Woodside, M. (2017). Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories. Nature Communications.

Scholl, Z. N., Yang, W. & Marszalek, P. E. Reconstructing the Folding of Luciferase to Elucidate the Vectorial Folding Pathways of Large, Multidomain Proteins. Biophysical Journal.

Scholl, Z. N., Li, Q., Yang, W. & Marszalek, P. E. (2016). Single-molecule force-spectroscopy reveals the calcium dependency of folding intermediates in the multidomain Protein S. Journal of Biological Chemistry.

Gonzalez, M. A., Simon, J. R., Ghoorchian A., Scholl, Z. N., Lin, S., Rubinstein, M., Marszalek, P., Chilkoti, A., Lopez G. P., Zhao, Z. (2016). Strong, tough, stretchable and self-adhesive hydrogels from instrinsically unstructured proteins. Advanced Materials.

Josephs, E.A., Scholl, Z. N., & Marszalek, P. E. (2016). AFM Force Spectroscopy. Introduction to Single Molecule Biophysics Book.

Scholl, Z. N.*, Josephs, Eric.*, & Marszalek, P. E. (2016). A Modular, Non-Degenerate Polyprotein Scaffold for Atomic Force Spectroscopy. Biomacromolecules.

Scholl, Z. N.*, Zhong, J.*, Hartemink, A. J. (2015). Chromatin interactions correlate with local transcriptional activity in Saccharomyces cerevisiae. bioRxiv.

Scholl, Z. N., Yang, W., & Marszalek, P. E. (2015). Direct Observation of Multimer Stabilization in the Mechanical Unfolding Pathway of a Protein Undergoing Oligomerization. ACS Nano.

Li, Q., Scholl, Z. N., & Marszalek, P. E. (2014). Capturing the Mechanical Unfolding Pathway of a Large Protein with Coiled-Coil Probes. Angewandte Chemie International Edition.

Scholl, Z. N., Yang, W., & Marszalek, P. E. (2014). Chaperones Rescue Luciferase Folding by Separating its Domains. Journal of Biological Chemistry, M114.582049.

Scholl, Z. N., & Marszalek, P. E. (2014). Unraveling the Mysteries of Chaperone Interactions of the Myosin Head. Biophysical journal, 107(3), 541-542. (Commentary)

Li, Q., Scholl, Z. N., & Marszalek, P. E. (2014). Nanomechanics of Single Biomacromolecules. In Handbook of Nanomaterials Properties (pp. 1077-1123). Springer Berlin Heidelberg.

Scholl, Z. N., & Marszalek, P. E. (2014). Improving single molecule force spectroscopy through automated real-time data collection and quantification of experimental conditions. Ultramicroscopy, 136, 7-14.

Scholl, Z. N., Li, Q., & Marszalek, P. E. (2014). Single molecule mechanical manipulation for studying biological properties of proteins, DNA, and sugars. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 6(3), 211-229.

Scholl, Z. N.*, Rabbi, M.*, Lee, D., Manson, L., Hanna, S., & Marszalek, P. E. (2013). Origin of Overstretching Transitions in Single-Stranded Nucleic Acids. Physical review letters, 111(18), 188302.

Loksztejn, A., Scholl, Z. N., & Marszalek, P. E. (2012). Atomic force microscopy captures folded ribosome bound nascent chains. Chem. Commun., 48(96), 11727-11729.

Magwene, P. M., Kayikci, O., Granek, J. A., Reininga, J. M., Scholl, Z. N., & Murray, D. (2011). Outcrossing, mitotic recombination, and life-history trade-offs shape genome evolution in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences, 108(5), 1987-1992.

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